Death, danger & immunity: Fundamental mechanisms linking pathogenic or iatrogenic cell death events to immune responses

Immune Activation: Death, Danger and Dendritic Cells

Dendritic cells are critical for host immunity, and sense microbes with pathogen recognition receptors. New evidence indicates that these cells also sense uric acid crystals in dead cells, suggesting that the immune system is conscious not only of pathogens, but also of death and danger.

Ironing Out Cell Death Mechanisms

lamin gene (Lmna) develop an EDMD-like syndrome soon after birth and die within 6 weeks of cardiovascular disease. A recent publication by Chen et al. (2012) reports the remarkable finding that downregulation of Sun1 expression in Lmnadeficient mice significantly extended their life span along with amelioration of cardiac pathology. Thus, LINC complexes could represent viable therapeutic target...

Halfway to Death

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Neuronal death and survival - targeting glutamate-induced cell death mechanisms

Death-associated protein kinase-mediated cell death modulated by interaction with DANGER.

Death-associated protein kinase (DAPK) is a key player in multiple cell death signaling pathways. We report that DAPK is regulated by DANGER, a partial MAB-21 domain-containing protein. DANGER binds directly to DAPK and inhibits DAPK catalytic activity. DANGER-deficient mouse embryonic fibroblasts and neurons exhibit greater DAPK activity and increased sensitivity to cell death stimuli than do ...